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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Progressive plasticity during colorectal cancer metastasis
Biorxiv : the Preprint Server for Biology
|September 4, 2023
Summary
Metastatic colorectal cancer cells lose intestinal states and gain plasticity, differentiating into fetal progenitor and divergent cell types. This reprogramming, worsened by chemotherapy, is linked to poorer patient survival.
Area of Science:
- Oncology
- Cancer Biology
- Cellular Reprogramming
Background:
- Metastasis is the primary cause of cancer mortality, but metastatic cell states and their origins remain poorly understood.
- Colorectal cancer (CRC) progression involves transitions from primary tumors to metastatic sites, yet the underlying cellular mechanisms are unclear.
Conclusions:
- Metastatic colorectal cancer cells undergo a plastic reprogramming process involving dedifferentiation and aberrant differentiation.
- Chemotherapy can exacerbate this reprogramming, negatively impacting patient outcomes.
- PROX1 plays a critical role in maintaining intestinal lineage identity and its loss promotes metastatic plasticity.
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