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Updated: Jul 17, 2025

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
Published on: July 29, 2017
Metastatic carcinoma of unknown origin in a dog
Alysha M McGrath1, Matthew R Cook1, Ching Yang1
1Department of Veterinary Clinical Sciences (McGrath, Cook, Lumbrezer-Johnson, Hostnik, Lapsley, Tremolada, Selmic) and Department of Veterinary Biosciences (Premanandan), College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, Ohio 43210, USA; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, Pennsylvania 19104, USA (Yang).
Abstract:
Although cancer of unknown primary origin (CUP) is well-described in the human literature, it is not as well-understood within veterinary medicine. This case report represents one of few focused on describing CUP in a dog. Key clinical message: Metastatic CUP should be considered as a differential diagnosis despite being a rare disease entity that is infrequently reported within the veterinary literature.

