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[Prostatic cancer: pathological analysis of autopsied cases]
Hinyokika Kiyo. Acta Urologica Japonica
|June 1, 1986
Summary
Histopathologic grading of prostate cancer can change between biopsy and autopsy, and between primary tumors and metastases. Older patients with longer disease duration were more likely to show grade changes, often to a higher grade.
Area of Science:
- Oncology
- Pathology
Context:
- Prostate cancer diagnosis relies on histopathologic grading.
- Accurate grading is crucial for treatment decisions and prognosis.
Purpose:
- To compare prostate cancer histopathologic grading between biopsy, autopsy prostate, and autopsy metastatic lesions.
- To identify factors associated with grade changes in prostate cancer.
Summary:
- In 27 prostate cancer cases, histopathologic grading was compared across biopsy, autopsy prostate, and metastatic sites.
- Grade changes occurred in 14.8% between biopsy and autopsy prostate, and 11.1% between autopsy prostate and metastases.
- Cases with grade changes were older, had longer clinical courses, and tended to increase in grade.
Impact:
- Highlights potential discrepancies in prostate cancer grading over time and across disease sites.
- Suggests that age and clinical course may influence tumor grade evolution.
- Informs the understanding of prostate cancer progression and the reliability of initial grading.