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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

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Updated: Jul 17, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

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Published on: August 12, 2018

Progressive Multifocal Encephalopathy Holmes Tremor Successfully Treated with Bilateral Deep Brain Stimulation.

Talita D Rosa¹, Laura Dixon¹, Muhammad Ismail Khalid Yousaf¹

¹University of Louisville School of Medicine, Department of Neurology, US.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)

|September 4, 2023

Summary

Deep brain stimulation (DBS) effectively treated bilateral Holmes tremor (HT) in an HIV/AIDS patient with progressive multifocal encephalopathy. This first-in-kind bilateral VIM/PSA DBS approach showed no significant side effects and improved tremor control.

Area of Science:

Neurology
Neurosurgery
Infectious Diseases

Background:

A 58-year-old male with HIV/AIDS and progressive multifocal leukoencephalopathy (PML) experienced a 20-year history of bilateral arm tremor.

Keywords:

Deep brain Stimulation Homes tremor Rubral Tremor Tremor

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The tremor was refractory to conventional therapies, significantly impacting daily activities.