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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
Published on: April 18, 2011
Restless legs syndrome
Budhima Nanayakkara1, James Di Michiel2, Brendon J Yee3
1PhB (Hons), MBBS (Hons1), FRACP, Associate Professor in Medicine, School of Rural Medicine, Charles Sturt University, Orange, NSW; Director of Prevocational Education and Training, Orange Health Service, Orange, NSW; Staff Specialist Respiratory and Sleep Physician, Orange Health Service, Orange, NSW.
Background:
Restless legs syndrome (RLS) is a common sensorimotor disorder causing significant distress and is commonly seen in the primary care setting.
Objective:
This article outlines the epidemiology, pathophysiology, diagnosis and management of RLS, with a focus on the primary care setting.
Discussion:
RLS is a clinical diagnosis, although mimics exist. Brain iron deficiency, dopaminergic dysfunction and genetics underpin the poorly understood pathophysiology of this common condition. After repleting iron stores, reviewing any exacerbating medications and attending to non-pharmacological management options, there are pharmacological options that prove to be effective, although with class-specific effects that need to be considered.
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