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Updated: Jul 17, 2025

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
A Quality Improvement Project: Implementation of the Centers for Disease Control and Prevention's Hepatitis C Virus
Julija A Joy1, Jennie Gunn, Madhuri S Mulekar
1Julija A. Joy, DNP, FNP-C Jennie Gunn, PhD, FNP-BC, CTN-A, and Madhuri S. Mulekar, PhD, University of South Alabama, Mobile, AL.
Purpose:
This quality improvement project was introduced at an addiction treatment center to implement the Centers for Disease Control and Prevention's (CDC's) hepatitis C virus (HCV) treatment guidelines and offer anticraving medications to patients to improve standards of care of patients with substance use disorders.
Literature Review:
Patients with opioid use disorders are at the highest risk of contracting HCV. More than 80% of people in the United States with opioid use disorders who use intravenous drugs have contracted HCV. Despite the high prevalence of HCV, patients at treatment centers are being screened only for HCV antibodies (HCV-AB) and are not receiving the CDC's HCV treatment guidelines. The CDC has treatment recommendations of hepatitis panels, full STD testing, and early follow-up care.
Method:
This quality improvement project utilized the Plan-Do-Study-Act tool. With the application of Plan-Do-Study-Act, for patients identified with HCV-AB, the established CDC HCV treatment guidelines were followed, and the clinical progress of the implementation of the guidelines was monitored. Chart reviews comparing compliance of guidelines before and after the study were implemented.
Participants:
A convenience sample of 125 patients were collected, and of these, 32 patients were found to be HCV-AB+.
Findings:
The findings revealed that 18.75% of patients followed the CDC's HCV recommendations after the quality improvement project compared with 6.25% of patients before the intervention. The number of HIV testing offered increased by 40.00% as a result of the implementation of the project.
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