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Cutaneous Adverse Events and Cancer Survival Prognosis With Immune Checkpoint Inhibitor Treatment: A Systematic
Yaxin Du1, Wenjie Wu1, Mei Chen1
1Department of Dermatology, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.
JAMA Dermatology
|September 6, 2023
Summary
Cutaneous immune-related adverse events (cirAEs) in cancer patients receiving immune checkpoint inhibitors (ICIs) are linked to better overall survival and progression-free survival. These skin-related side effects may serve as a valuable prognostic indicator during ICI therapy.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment.
- Cutaneous immune-related adverse events (cirAEs) are common side effects of ICI therapy.
- The prognostic significance of cirAEs in patients undergoing ICI treatment requires further elucidation.
Approach:
- A systematic review and meta-analysis was conducted to evaluate the association between cirAEs and cancer prognosis.
- Searches of major databases (PubMed, Embase, Cochrane Library, Web of Science) were performed up to May 2023.
- Twenty-three studies comprising 22,749 patients treated with ICIs were included in the analysis.
Key Points:
- The presence of cirAEs was significantly associated with improved overall survival (OS) and progression-free survival (PFS) in patients receiving ICIs.
- Hazard ratios indicated a reduced risk of mortality and disease progression for patients experiencing cirAEs.
- Consistent positive prognostic associations were observed across various subgroups, including cancer type, ICI type, and study design.
Conclusions:
- Cutaneous immune-related adverse events are associated with favorable outcomes in cancer patients treated with ICIs.
- CirAEs may serve as a valuable predictive biomarker for treatment response and prognosis in the context of ICI therapy.
- These findings underscore the importance of monitoring and managing cirAEs for optimizing cancer patient care.
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