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Updated: Jul 17, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Gene Therapy for Immunoglobulin E, Complement-Mediated, and Eosinophilic Disorders
Odelya E Pagovich1, Ronald G Crystal1
1Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA.
Abstract:
Immunoglobulin E, complement, and eosinophils play an important role in host defense, but dysfunction of each of these components can lead to a variety of human disorders. In this review, we summarize how investigators have adapted gene therapy and antisense technology to modulate immunoglobulin E, complement, and/or eosinophil levels to treat these disorders.
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