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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

162
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
162
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

363
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
363
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

200
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

265
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
265
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

262
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
262
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
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Advances in TB testing.

Jayson V Pagaduan1, Ghaith Altawallbeh1

  • 1Intermountain Central Laboratory Intermountain Medical Center, Murray, UT, United States.

Advances in Clinical Chemistry
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PubMed
Summary
This summary is machine-generated.

Tuberculosis (TB) remains a major global health threat, causing millions of deaths annually. Improved diagnostic tools for both active and latent TB are crucial for achieving the End TB goal.

Keywords:
Interferon gamma release assaysLatent TB infectionMycobacterium tuberculosisNucleic acid amplification testTuberculin skin testTuberculosisTuberculosis antigen-based skin test

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Tuberculosis (TB) was a leading cause of death from a single infectious agent globally until the COVID-19 pandemic.
  • In 2020, 10 million people contracted TB, and 1.5 million died.
  • Approximately two billion people are latently infected with Mycobacterium tuberculosis (MTB), with a 5-10% lifetime risk of progression to active TB.

Purpose of the Study:

  • To review current World Health Organization (WHO)-endorsed diagnostic tests for TB.
  • To discuss advancements in diagnostic and screening tests for both active and latent TB.
  • To highlight the importance of improved diagnostics for achieving the End TB 2035 goal.

Main Methods:

  • Review of current WHO-endorsed diagnostic technologies for TB.
  • Analysis of recent technological advancements in TB diagnostics.
  • Discussion of screening strategies for latent TB infection (LTBI).

Main Results:

  • Current diagnostic methods and their limitations are presented.
  • Emerging technologies for more accurate and accessible TB diagnosis are explored.
  • The critical role of diagnosing and treating latent TB is emphasized.

Conclusions:

  • Accurate and accessible diagnostic tools are essential for TB control.
  • Advancements in diagnostic technology are crucial for identifying and treating latently infected individuals.
  • Achieving the End TB goal requires significant improvements in diagnostic capabilities for both active and latent TB.