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Related Experiment Video

Updated: Jul 17, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Post-stroke Headache.

Monica Chan1,2, Alison Thaler3,4

  • 1Division of Headache and Facial Pain, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. Monicachan15@gmail.com.

Current Pain and Headache Reports
|September 7, 2023
PubMed
Summary
This summary is machine-generated.

Persistent post-stroke headache (PPSH) affects 1-23% of stroke survivors, often mimicking tension-type headaches. Further research is needed to understand PPSH characteristics and optimize treatment strategies.

Keywords:
CGRPMigrainePost-stroke complicationPost-stroke headacheTension-type headacheTriptan

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Area of Science:

  • Neurology
  • Headache Medicine
  • Stroke Rehabilitation

Background:

  • Stroke is a leading cause of disability, with persistent post-stroke headache (PPSH) being a common complication.
  • PPSH is poorly understood, lacking specific diagnostic criteria and established management guidelines.
  • The 2018 International Classification of Headache Disorders, 3rd edition (ICHD-3) first included diagnostic criteria for PPSH.

Purpose of the Study:

  • To review the epidemiology, presentation, and hypothesized pathophysiology of PPSH.
  • To discuss current and emerging treatment options for PPSH, including triptans and CGRP antagonists.
  • To highlight the need for further research into PPSH management and efficacy.

Main Methods:

  • Literature review of studies on persistent post-stroke headache.
  • Analysis of diagnostic criteria and prevalence estimates for PPSH.
  • Synthesis of information on hypothesized pathophysiological mechanisms and treatment approaches.

Main Results:

  • PPSH prevalence ranges from 1% to 23% in post-stroke patients.
  • Headache presentation is variable, frequently resembling tension-type headache.
  • No evidence-based guidelines currently exist for optimal PPSH treatment.

Conclusions:

  • PPSH is a common yet under-researched complication of stroke.
  • Understanding PPSH epidemiology and pathophysiology is crucial for developing effective treatments.
  • Further investigation into the efficacy and safety of acute and preventive therapies is warranted.