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Nirmatrelvir/ritonavir use in patients with COVID-19 on hemodialysis: a case series

Ai-Hua Zhang1, Zong-Li Diao1, Gang Wang1

  • 1Renal Division, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.

Diagnostic Microbiology and Infectious Disease
|September 7, 2023
PubMed

Insights

Nirmatrelvir/ritonavir (N/R) shows promise for treating COVID-19 in hemodialysis patients. This small study found symptom improvement and viral load reduction with manageable side effects after dosage adjustments.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Pharmacology

Background:

  • Patients on hemodialysis (HD) face higher risks for severe COVID-19.
  • Limited clinical trial data exist for nirmatrelvir/ritonavir (N/R) in HD populations.

Observation:

  • N/R was administered to four HD patients with COVID-19 under informed consent.
  • Clinical symptoms improved around day 3 post-administration.
  • Viral load reduction was observed approximately 10 days after N/R initiation.

Findings:

  • Nirmatrelvir/ritonavir demonstrated clinical improvement and viral load reduction in HD patients with COVID-19.
  • Common adverse effects included nausea and vomiting.
  • Dosage adjustments improved tolerance without compromising efficacy.

Implications:

  • Nirmatrelvir/ritonavir may be an effective treatment option for COVID-19 in hemodialysis patients.
  • Further research is warranted to confirm N/R efficacy and safety in this vulnerable group.
  • This study highlights the potential for therapeutic interventions in underrepresented patient populations.

Keywords:
COVID-19HemodialysisNirmatrelvir/ritonavir

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