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Advances in the treatment of gastric cancer: 2022-2023

David H Ilson1

  • 1Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, Weill-Cornell Medical College, New York, New York, USA.

Current Opinion in Gastroenterology
|September 7, 2023
PubMed
Abstract

Insights

Recent gastric cancer research highlights immune checkpoint inhibitors for advanced disease and MSI-high tumors. Laparoscopic surgery is viable, and zolbetuximab shows promise for claudin 18.2-positive metastatic gastric cancer.

Area of Science:

  • Gastroenterology and Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Gastric cancer remains a significant global health challenge.
  • Advances in treatment strategies are crucial for improving patient outcomes.
  • The 2022-2023 literature provides key insights into novel therapeutic approaches.

Purpose of the Study:

  • To review recent (2022-2023) significant studies in gastric cancer treatment.
  • To synthesize findings on surgical techniques, immunotherapy, and targeted therapy.

Main Methods:

  • Literature review of studies published between 2022 and 2023.
  • Analysis of clinical trial data regarding surgical approaches, immune checkpoint inhibitors, and targeted agents.
  • Evaluation of survival data, response rates, and pathological outcomes.

Main Results:

  • Laparoscopic gastrectomy demonstrates comparable survival to open surgery.
  • Immune checkpoint inhibitors show efficacy in metastatic, locally advanced, and adjuvant settings for specific gastric cancer subtypes.
  • Zolbetuximab, targeting claudin 18.2, significantly improved overall survival in metastatic gastric cancer.
  • Neoadjuvant ipilimumab and nivolumab achieved high pathologic complete response rates in MSI-high gastric cancer.

Conclusions:

  • Immune checkpoint inhibition is a valuable strategy for locally advanced MSI-high and metastatic gastric cancer.
  • Laparoscopic gastrectomy is an acceptable surgical option for gastric cancer.
  • Zolbetuximab is emerging as a new therapeutic option for metastatic gastric cancer.

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