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Updated: Jul 16, 2025

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
Mental Health in Women
Syed Azharuddin1, Katherine Vital-Daley, Victoria Mustovic
1Psychiatry and Behavioral Health Institute (Drs Vital-Daley, Mustovic, and Swanson), Division of Pulmonary and Critical Care Medicine (Drs Azharuddin, Marshall, DuMont, and Barker), and Division of Nursing, Allegheny General Hospital (Mr Calvin), Allegheny Health Network, Pittsburgh, Pennsylvania.
Abstract:
Mental health illness has been increasing worldwide. The prevalence of mental illness and is higher among females than among males. It is estimated that one in 5 women experience a common mental health disorder. This article highlights gender disparities in the risk, prevalence, and presentation of different mental health disorders. Nearly all survivors of critical illness experience 1 or more domains of the post-intensive care syndrome. We review different mental health disorders including anxiety disorders, mood disorders, psychotic disorders, and post-intensive care syndrome, and medications used to manage these disorders. Delirium in the intensive care unit can be misdiagnosed as a primary psychiatric disorder and is important to distinguish from each other. We also highlight the inadequacy of surveillance and recognition of mental health disorders in the intensive care unit, leading to missed opportunities to properly manage these important psychiatric conditions.
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