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This review highlights recent advances in enantioselective synthesis employing radical reactions. It details methods for creating chiral molecules using various catalytic approaches, including metal and organocatalysis.

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Area of Science:

  • Organic Chemistry
  • Catalysis
  • Asymmetric Synthesis

Background:

  • Chiral molecules are crucial in pharmaceuticals and materials science.
  • Enantioselective synthesis aims to produce specific stereoisomers.
  • Radical reactions offer unique pathways for molecular construction.

Purpose of the Study:

  • To review enantioselective synthesis strategies using radical reactions published since 2017.
  • To summarize recent catalytic approaches for asymmetric synthesis.
  • To identify obtainable enantiomerically enriched compounds.

Main Methods:

  • Literature review of research since 2017.
  • Focus on radical reaction methodologies.
  • Analysis of catalytic systems: metal, dual metal, organocatalysis, and enzyme catalysis.

Main Results:

  • Overview of diverse enantioselective radical reactions.
  • Demonstration of various catalytic systems for asymmetric synthesis.
  • Identification of accessible chiral compounds with high enantiomeric enrichment.

Conclusions:

  • Enantioselective radical reactions are a powerful tool for synthesizing chiral molecules.
  • Catalysis, particularly metal and organocatalysis, plays a key role.
  • Significant progress has been made in achieving high enantioselectivity since 2017.