Electrospun Nanofiber Membranes with Various Structures for Wound Dressing.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Electrospun nanofiber membranes (NFMs) possess high porosity and large surface area, ideal for wound healing.
• Their structure mimics the human dermis extracellular matrix, promoting hemostasis, anti-inflammatory responses, and healing.
• NFMs are extensively researched for wound dressing applications.

Purpose of the Study:

• To review the evolution of electrospinning technology for wound dressings.
• To analyze the application of electrospun nanofibers in wound healing.
• To highlight material selection, therapeutic factor incorporation, and structural design of NFMs.

Main Methods:

• Overview of electrospinning history and principles.
• Focus on material selection for electrospun nanofibers.
• Analysis of therapeutic factor incorporation and structural design of NFMs.

Main Results:

• Electrospun NFMs facilitate wound healing through hemostasis, antibacterial properties, and cell proliferation.
• Various structural designs (porous, core-shell, multilayer) enhance NFM functionality.
• The review classifies NFMs based on therapeutic functions for wound healing.

Conclusions:

• Electrospun nanofibers represent a promising platform for advanced wound dressings.
• Structural design and therapeutic factor integration are key to optimizing NFM performance.
• Further research is needed to address limitations and challenges in clinical application.