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Updated: Jul 16, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis, characterization and crystal structure of methyl 2-(2-oxo-2H-chromen-4-yl-amino)-benzoate
Henrique V P Hollauer1, Rachel C Vilas Novas1, Guilherme P Guedes2
1Chemistry Department, Pontifical Catholic University of Rio de Janeiro, 22451-900 Rio de Janeiro, RJ, Brazil.
Abstract:
Methyl 2-(2-oxo-2H-chromen-4-yl-amino)-benzoate, C17H13NO4 (1), was pre-pared by condensation between 4-hy-droxy-coumarin and methyl 2-amino-benzoate. It crystallizes in the ortho-rhom-bic space group Pca21 at 300 K. The mol-ecule of compound 1 consists of the 2H-chromen-2-one part connected by an amine moiety (-NH-) to the methyl benzoate ring. The supra-molecular array is formed by hydrogen bonds between the aromatic ring and the O atoms of the lactone and ester portions. The structural details match the spectroscopic data acquired from NMR and IR spectroscopy.
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