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Fe Single-Atom Nanozyme-Modified Wearable Hydrogel Patch for Precise Analysis of Uric Acid at Rest
Yong Zhang1, Changjun Hou1, Peng Zhao1
1Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, PR China.
ACS Applied Materials & Interfaces
|September 11, 2023
Summary
This study presents a wearable patch for precise, noninvasive analysis of uric acid (UA) in resting sweat. The device utilizes Fe single-atom nanozymes and pH calibration for accurate metabolic monitoring, advancing personalized medicine.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Wearable Technology
Background:
- Resting sweat analysis offers insights into metabolic health but faces challenges due to low sweat rates and molecule concentrations.
- Noninvasive wearable sensors are crucial for continuous physiological monitoring.
Purpose of the Study:
- To develop a wearable patch for precise, noninvasive detection of uric acid (UA) in resting sweat.
- To address the limitations of low sweat secretion and low analyte concentration for wearable sensor development.
Main Methods:
- Fabrication of a wearable patch incorporating Fe single-atom nanozymes (FeSAs) for selective UA catalysis.
- Integration of polyaniline for simultaneous pH detection and calibration of UA measurements.
- Optimization of sweat collection using agarose hydrogels to reduce accumulation time.
Main Results:
- Demonstrated selective and sensitive detection of uric acid (1-425 μM) using FeSAs.
- Achieved accurate UA analysis in volunteer sweat samples through pH calibration.
- Verified the feasibility of the wearable patch for resting sweat analysis.
Conclusions:
- The developed wearable patch enables precise, noninvasive monitoring of resting sweat uric acid.
- This technology offers novel insights for personalized medicine through advanced wearable diagnostics.
- The study advances the field of wearable biosensors for metabolic health assessment.
