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In Vivo Evaluation of Chitosan-Titanium Dioxide Nanopowder as Wound Dressing Material
Nusaiba Al-Nemrawi1, Ruba S Darweesh1, Dana Alrousan1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Recent Advances in Drug Delivery and Formulation
|September 13, 2023
Summary
Chitosan-Titanium dioxide nanopowder films show enhanced antibacterial properties and accelerate wound healing in rats. These novel wound healing films offer a promising alternative for drug delivery applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Flexible, robust, and adherent films are crucial for effective wound healing, preventing maceration.
- Chitosan (CS) and Titanium dioxide nanopowder (TiO2 NP) possess properties beneficial for wound healing acceleration and film preparation.
Purpose of the Study:
- To formulate and characterize Chitosan-Titanium dioxide nanopowder composite films for wound healing applications.
- To assess the physical, thermal, chemical, mechanical, and antibacterial properties of the developed films.
- To evaluate the in vivo efficacy of the films in promoting wound healing in a murine model.
Main Methods:
- Films were fabricated using Chitosan and Titanium dioxide nanopowder.
- Characterization involved FTIR, TGA, DSC, XRD, and SEM analyses.
- Mechanical properties, antimicrobial activity, and in vivo wound healing performance in rats were evaluated.
Main Results:
- CS-TiO2 films exhibited increased weight and thickness but reduced flexibility compared to CS-only films.
- The selected CS-TiO2 film demonstrated excellent folding endurance, with a surface pH of 5.18.
- CS-TiO2 films displayed significant broad-spectrum antibacterial activity, outperforming CS films, and accelerated wound healing in rats.
Conclusions:
- Composite films of Titanium dioxide nanopowder and Chitosan possess suitable properties for wound healing applications.
- These films show potential for future development in drug delivery systems for enhanced wound management.
