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Updated: Aug 9, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
Published on: April 12, 2019
Graphical analysis of circular dichroic spectra distinguishes between two-state and gradual alterations in DNA
Abstract:
A simple graphical method is proposed to distinguish between two-state and gradual alterations in DNA conformation from circular dichroic spectra. The method is advantageous particularly to identify two-state conformational isomerizations which exhibit low degree of cooperativity. The usefulness of the method is illustrated on the examples of two synthetic DNA molecules which isomerize due to temperature changes or changes in salt concentration. The method can be used to characterize any phenomenon accompanied by alterations in optical activity.
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