Rabbit systemic glucose metabolism map by total-body dynamic PET/CT technology

Area of Science:

• Preclinical imaging
• Nuclear medicine
• Metabolic research

Background:

• Evaluating total-body glucose metabolism is crucial for understanding physiological and pathological states.
• Rabbits serve as a valuable preclinical model for studying human metabolic processes.

Purpose of the Study:

• To establish a dynamic total-body glucose metabolic atlas in rabbits using 18F-FDG PET/CT.
• To assess glucose metabolism heterogeneity and correlations with physiological functions.

Main Methods:

• Utilized a dynamic total-body PET/CT system for imaging 10 sedated rabbits.
• Quantified glucose metabolism using 18F-FDG Standard Uptake Values (SUV).
• Analyzed metabolic differences between sexes and bilateral sides.

Main Results:

• Demonstrated significant heterogeneity in glucose distribution across various organs.
• Observed no significant metabolic differences between sexes or left/right sides.
• Identified higher 18F-FDG uptake in the heart, liver, and urinary system, and lower uptake in skeletal muscle, brain, spinal cord, and lungs.

Conclusions:

• The developed total-body glucose metabolic atlas serves as a reference for pathological 18F-FDG uptake assessment.
• This study provides a foundational reference for preclinical research on glucose metabolism abnormalities.