[The spectrum of transient acantholytic dermatoses]

Area of Science:

• Dermatology
• Histopathology

Background:

• Transient acantholytic dermatosis (TAD) is a rare skin condition.
• Classical Grover's disease is the most recognized form of TAD.
• Differentiating TAD from other blistering and papular skin diseases can be challenging.

Observation:

• A literature review was conducted to expand the definition of TAD.
• The study aimed to categorize the diverse clinical presentations of TAD.
• Three novel cases of a bullous exanthematic variant of TAD were identified.

Findings:

• The study proposes a broader classification of TAD beyond classical Grover's disease.
• Distinct clinical pictures associated with TAD were systematically categorized.
• The bullous exanthematic variant represents a previously undescribed manifestation of TAD.

Implications:

• This expanded classification aids in diagnosing and managing a wider range of TAD presentations.
• Distinguishing TAD from Darier's disease, Hailey-Hailey disease, and immunofluorescence-positive acantholytic dermatoses is clarified.
• The identification of a new variant expands the understanding of TAD's clinical spectrum.