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Published on: August 11, 2015
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Morphological characteristics of brain aneurysms among age groups
Sebastian Sanchez1, Muhammed Amir Essibayi2, Meredith Hickerson1
1Department of Neurology, University of Iowa, USA.
Summary
Brain aneurysm rupture risk varies by age. Younger patients have smaller, often MCA/ACOM located aneurysms, while older patients have larger, more irregular aneurysms, frequently in the PCOM/ACOM. Irregularity increases rupture risk across all ages.
Area of Science:
- Neurology
- Vascular Surgery
- Radiology
Background:
- Patient age is a critical factor in aneurysm rupture risk.
- Limited data exists on age-related differences in brain aneurysm morphology.
- This study investigates morphological variations in brain aneurysms across different age groups.
Purpose of the Study:
- To analyze the morphological characteristics of brain aneurysms in relation to patient age.
- To identify age-specific patterns in aneurysm location, size, and shape.
- To assess the impact of morphology and age on aneurysm rupture risk.
Main Methods:
- Analysis of 1407 unruptured and 607 ruptured saccular aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR).
- Evaluation of aneurysm parameters including location, size, neck dimensions, aspect ratio, and morphology (regular vs. irregular).
- Logistic regression used to estimate rupture risk presentation.
Main Results:
- Aneurysm size increased with age for unruptured cases (p < .001), but not for ruptured cases (p = .142).
- Ruptured aneurysm locations differed by age: MCA/ACOM in younger (<70) vs. PCOM/ACOM in older (>70) patients.
- Both unruptured and ruptured aneurysms showed increased irregularity with older age (p < .001 and p = .025, respectively).
Conclusions:
- Younger patients (<70) present with smaller aneurysms, predominantly in the MCA/ACOM, with rupture risk influenced by location and irregularity.
- Older patients (>70) present with larger, more irregular unruptured aneurysms, with ruptured aneurysms often in the PCOM/ACOM.
- Irregular aneurysm morphology is a significant risk factor for rupture across all age demographics.
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