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Updated: Jul 16, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in

Siwei Zhang1,2, Hanwen Zhang1, Marc P Forrest3,4

  • 1Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA.

Cell Genomics
|September 18, 2023
PubMed

Keywords:
CRISPR-Cas9 gene editingCROP-seqGWASMicro-Callele-specific open chromatinchromatin accessibilitycommon risk variantshuman iPS cellsisogenicneuronneuropsychiatric disordersnoncoding variantsscRNA-seqschizophreniasynergistic

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