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Related Experiment Video

Updated: Jul 16, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
07:44

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

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A human cadaveric model for venous air embolism tool development.

Nathaniel L Robinson1, Chris Marcellino1, Matt Johnston1

  • 1Mayo Clinic.

Research Square
|September 18, 2023
PubMed
Summary

A novel human cadaver model was developed to detect venous air emboli (VAE) using mechanical ventilation and modified bypass. This approach enables technology development for VAE monitoring, reducing animal and human testing.

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Articles linked to this work by shared authors, journal, and citation graph.

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Patterns of remimazolam use and recovery after procedural sedation and anaesthesia: a multicentre cohort study.

BJA open·2026
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Motivation and perceived learning in serious games: Reflexive thematic analysis of educational escape room experiences.

Medical teacher·2026
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Pathogenic PF4/Polyanion ELISA-Negative Antibodies in HIT.

American journal of hematology·2026
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Assessment of Anesthesia Practice Patterns for Management of Neurosurgical Cases With Risk of Venous Air Embolism: An International Survey of Anesthesiologists.

Journal of neurosurgical anesthesiology·2026
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Pathogenic PF4/Polyvinylsulfonate ELISA-negative Antibodies in HIT.

medRxiv : the preprint server for health sciences·2025
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Time-Domain Analysis of Chest Impedance for Venous Air Embolism Detection: An Open-Source Software Tool and Single-Cadaver Pilot Study.

Cureus·2025

Area of Science:

  • Medical Simulation
  • Cardiopulmonary Research
  • Anatomical Modeling

Background:

  • Venous air emboli (VAE) pose a significant risk during medical procedures.
  • Current methods for VAE detection and monitoring require further refinement.
  • In vivo testing in humans and animals presents ethical and practical challenges.

Conclusions:

  • A human cadaver model offers a viable platform for developing and testing VAE monitoring technologies.
  • This model reduces the reliance on animal and conventional human testing for technological advancement.
  • The developed model supports the investigation of novel detection modalities like echocardiography and ultrasound.
Keywords:
VAEair embolismcadaverneurosurgery

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