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Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study
Fathia M Khattab1, Mai A Samir1, Shaimaa S El Khouly1
1All authors are with the Department of Dermatology, Venereology and Andrology, and Faculty of Medicine at Zagazig University in Zagazig, Egypt.
The Journal of Clinical and Aesthetic Dermatology
|September 18, 2023
Summary
Polycaprolactone (PCL) threads significantly improved atrophic acne scars more effectively than microneedling with platelet-rich plasma (PRP). Both treatments showed good results and patient satisfaction, with PCL threads offering superior outcomes.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Regenerative Medicine
Background:
- Polycaprolactone (PCL) threads are emerging as a novel treatment for skin rejuvenation by stimulating collagen production.
- Atrophic acne scars represent a significant aesthetic concern, prompting research into effective treatment modalities.
Purpose of the Study:
- To compare the efficacy and safety of PCL threads versus microneedling combined with autologous platelet-rich plasma (PRP) for treating atrophic acne scars.
- To evaluate patient satisfaction and clinical outcomes between the two treatment groups.
Main Methods:
- A split-face study design was employed with 24 participants (20-37 years) having atrophic acne scars.
- One side of the face received a single session of PCL threads, while the other side underwent four sessions of microneedling with PRP.
- Outcomes were assessed using a global scarring grading system and patient satisfaction surveys over a six-month follow-up period.
Main Results:
- A higher percentage of patients (95.8%) showed significant clinical improvement with PCL threads compared to microneedling with PRP (83.3%).
- Patient satisfaction was markedly higher in the PCL threads group (p<0.0001).
- Reported side effects, including mild edema and erythema, were transient and tolerable for both treatments.
Conclusions:
- PCL threads and microneedling with PRP are effective in treating atrophic acne scars, offering satisfactory results.
- PCL threads demonstrated superior efficacy and patient satisfaction compared to microneedling with PRP in this study.
- Both procedures are associated with minor, rapidly resolving side effects.
