Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
Radiation: Applications01:17

Radiation: Applications

1.2K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.2K
Absorption of Radiation01:05

Absorption of Radiation

761
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
761
Radiation Pressure: Problem Solving01:09

Radiation Pressure: Problem Solving

394
The radiation pressure applied by an electromagnetic wave on a perfectly absorbing surface equals the energy density of the wave. The wave's momentum also gets transferred to the surface when an electromagnetic wave is entirely absorbed by it. The rate at which momentum is transmitted to an absorbing surface perpendicular to the propagation direction equals the force on the surface.
The average value of the rate of momentum transfer divided by the absorbing area represents the average force...
394
Mutations01:35

Mutations

38.2K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
38.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generative and integrative modeling for transcriptomics with formalin fixed paraffin embedded material.

Journal of translational medicine·2025
Same author

Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy.

Breast cancer research : BCR·2025
Same author

Likely community transmission of COVID-19 infections between neighboring, persistent hotspots in Ontario, Canada.

F1000Research·2022
Same author

Pathway-extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors.

MedComm·2021
Same author

Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures.

International journal of radiation biology·2021
Same author

Differentially accessible, single copy sequences form contiguous domains along metaphase chromosomes that are conserved among multiple tissues.

Molecular cytogenetics·2021
Same journal

A proposal for a differentiated radiation protection program for the decommissioning of nuclear power plants compared to the operation of nuclear power plants.

Radiation protection dosimetry·2026
Same journal

A three-dimensional neutron localization method based on double-scattering imaging and reconstruction algorithm.

Radiation protection dosimetry·2026
Same journal

Effect of 131I biodistribution on measurements using a scanning whole-body counter.

Radiation protection dosimetry·2026
Same journal

Activity concentration of 137Cs and natural radionuclides in soil around the Belarusian nuclear power plant in the pre-commissioning period.

Radiation protection dosimetry·2026
Same journal

Novel passive-adaptive exoskeleton-supported radiation protection equipment with enhanced shielding and reduced perceived weight.

Radiation protection dosimetry·2026
Same journal

Feasibility of kV dose measurement in IGRT using MV-calibrated ionization chambers.

Radiation protection dosimetry·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
08:23

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Published on: December 25, 2021

4.9K

Radiation exposure determination in a secure, cloud-based online environment.

Ben C Shirley1, Eliseos J Mucaki2, Joan H M Knoll1,3

  • 1CytoGnomix Inc., 60 N. Centre Rd., London Ontario N5X 3X5, Canada.

Radiation Protection Dosimetry
|September 18, 2023
PubMed
Summary
This summary is machine-generated.

ADCI Online, a web-based system, rapidly estimates radiation exposure using the dicentric chromosome (DC) assay. This accelerates analysis for radiation incidents, improving triage and patient care.

More Related Videos

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K

Related Experiment Videos

Last Updated: Jul 16, 2025

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
08:23

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Published on: December 25, 2021

4.9K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.4K

Area of Science:

  • Radiation biology
  • Medical physics
  • Computational toxicology

Background:

  • Rapid assessment of radiation exposure is crucial for effective triage after radiological incidents.
  • The dicentric chromosome (DC) assay is a gold standard for biological dosimetry, but can be time-consuming.
  • Existing automated systems require dedicated hardware, limiting accessibility.

Purpose of the Study:

  • To enhance the accessibility and speed of radiation dose estimation using the Automated Dicentric Chromosome Identifier and Dose Estimator System (ADCI).
  • To develop a secure, web-streaming platform (ADCI Online) for global access to radiation exposure assessment.
  • To ensure data and software integrity within a cloud-based environment.

Main Methods:

  • Development of ADCI Online, a secure web-streaming platform utilizing cloud-based systems.
  • Separation of cloud-based data and software until linked for dose estimation.
  • Validation of dose estimates against the dedicated hardware ADCI system.
  • Performance evaluation through image processing, calibration curve generation, and dose estimation of test samples.

Main Results:

  • ADCI Online provides dose estimates identical to the dedicated ADCI system.
  • The system completed image processing, calibration, and dose estimation for 9 samples in under 2 days.
  • Multiple cloned software instances in cloud environments accelerated dose estimation to clinically relevant time frames.

Conclusions:

  • ADCI Online significantly broadens accessibility and accelerates radiation dose estimation.
  • The platform can alleviate analytical bottlenecks during intermediate-to-large scale radiation incidents.
  • This system offers a scalable and efficient solution for biological dosimetry in emergency preparedness.