Related Experiment Video
Updated: Jul 16, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.0K
Topical Roflumilast for Plaque Psoriasis
Ashley O'Toole1,2,3, Melinda Gooderham1,2,3
1SKiN Centre for Dermatology, Peterborough, ON, Canada.
Skin Therapy Letter
|September 21, 2023
Summary
Topical roflumilast 0.3% cream effectively treats plaque psoriasis in adolescents and adults. This non-steroidal, once-daily treatment offers proven safety and efficacy across various body areas.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Plaque psoriasis is a chronic inflammatory skin condition.
- Phosphodiesterase-4 (PDE4) inhibitors represent a therapeutic target for psoriasis.
- Roflumilast is a selective PDE4 inhibitor.
Approach:
- Review of clinical trial data for topical roflumilast 0.3% cream.
- Assessment of safety and efficacy in adolescent and adult populations.
- Evaluation of formulation and application characteristics.
Key Points:
- Topical roflumilast 0.3% cream is approved for plaque psoriasis treatment.
- Demonstrates significant efficacy and favorable tolerability in clinical studies.
- Unique formulation allows for once-daily application on most body areas, including sensitive regions.
Conclusions:
- Topical roflumilast 0.3% cream is a safe and effective non-steroidal treatment option for plaque psoriasis.
- Its once-daily dosing and broad applicability enhance patient adherence and convenience.
- Clinical trial evidence supports its use in adolescent and adult patients.
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