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Related Experiment Video

Updated: Jul 16, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Topical Roflumilast for Plaque Psoriasis.

Ashley O'Toole1,2,3, Melinda Gooderham1,2,3

  • 1SKiN Centre for Dermatology, Peterborough, ON, Canada.

Skin Therapy Letter
|September 21, 2023
PubMed
Summary
This summary is machine-generated.

Topical roflumilast 0.3% cream effectively treats plaque psoriasis in adolescents and adults. This non-steroidal, once-daily treatment offers proven safety and efficacy across various body areas.

Keywords:
PDE4 inhibitorintertriginous psoriasisinverse psoriasisplaque psoriasisroflumilasttopical therapy

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Plaque psoriasis is a chronic inflammatory skin condition.
  • Phosphodiesterase-4 (PDE4) inhibitors represent a therapeutic target for psoriasis.
  • Roflumilast is a selective PDE4 inhibitor.

Approach:

  • Review of clinical trial data for topical roflumilast 0.3% cream.
  • Assessment of safety and efficacy in adolescent and adult populations.
  • Evaluation of formulation and application characteristics.

Key Points:

  • Topical roflumilast 0.3% cream is approved for plaque psoriasis treatment.
  • Demonstrates significant efficacy and favorable tolerability in clinical studies.
  • Unique formulation allows for once-daily application on most body areas, including sensitive regions.

Conclusions:

  • Topical roflumilast 0.3% cream is a safe and effective non-steroidal treatment option for plaque psoriasis.
  • Its once-daily dosing and broad applicability enhance patient adherence and convenience.
  • Clinical trial evidence supports its use in adolescent and adult patients.