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Updated: Jul 16, 2025
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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
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Computed tomography perfusion software pipelines to assess parameter maps and ischemic volumes: A comparative study.
Wei Lu1, Feirong Yao2, Congguo Yin3
1ArteryFlow Technology Co., Ltd., Hangzhou, China.
Summary
AccuCTP and RAPID CTP software show excellent agreement for calculating infarct core volume and penumbra volume in acute ischemic stroke patients. AccuCTP can serve as a reliable alternative analysis tool in clinical practice.
Area of Science:
- Neuroimaging
- Stroke Imaging
- Medical Software Validation
Background:
- CT perfusion (CTP) is crucial for acute ischemic stroke assessment.
- Accurate measurement of infarct core volume (ICV) and penumbra volume (PV) is vital for treatment decisions.
- Evaluating agreement between CTP postprocessing software is essential for clinical utility.
Purpose of the Study:
- To investigate the agreement between two CTP postprocessing software packages: RAPID CTP and AccuCTP.
- To compare the calculated infarct core volume (ICV) and penumbra volume (PV) from both software.
- To assess the reliability of AccuCTP as an alternative to RAPID CTP.
Main Methods:
- Retrospective analysis of CTP data from 235 acute ischemic stroke patients.
- Comparison of ICV and PV measurements obtained from RAPID CTP and AccuCTP software.
- Statistical evaluation using Bland-Altman analysis, intraclass correlation coefficient (ICC), and root mean square error.
Main Results:
- AccuCTP and RAPID CTP demonstrated excellent agreement for ICV and PV.
- Parameter map differences were within 10%, with strong agreement shown by Bland-Altman analysis.
- High goodness of fit (R² > 0.96) and high ICC scores (ICV: 0.984, PV: 0.955) were observed.
Conclusions:
- AccuCTP results show excellent agreement with RAPID CTP.
- AccuCTP is a reliable alternative analysis tool for CTP in stroke clinical practice.
- Validated software agreement ensures consistent and accurate stroke assessment.
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