Related Experiment Video
Updated: Jul 16, 2025
12:19
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
10.9K
FEATURES OF BONE REMODELING AROUND SURFACE-MODIFIED TITANIUM AND TANTALUM IMPLANTS
Vasyli B Makarov1, Ninel V Dedukh2, Olga A Nikolchenko3
1CITY CLINICAL HOSPITAL № 16, DNIPRO, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|September 23, 2023
Summary
Titanium and tantalum implants with specific surface structures show promising osseointegration. Multilayered porous titanium and porous tantalum implants demonstrated superior bone-implant contact rates in animal studies.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Implantology
Background:
- Osseointegration is crucial for dental and orthopedic implant success.
- Surface structure significantly influences implant-bone interaction.
- 3D printing technology allows for precise control over implant surface topography.
Purpose of the Study:
- To evaluate and compare the osseointegrative properties of titanium and tantalum implants with varying surface structures.
- To assess the impact of 3D printed surface modifications on bone-implant contact and volume.
Main Methods:
- Histological and morphometric analysis of 60 male white rats.
- Implantation of titanium implants with multilayered interlaced pores (300 microns) and rough surfaces (>2 microns).
- Implantation of tantalum implants with 300-micron pores and 80% porosity as a control.
Main Results:
- Titanium implants with multilayered pores (59.91%) and tantalum implants (53.89%) showed significantly higher bone-implant contact rates than rough titanium (44.77%) at 30 days.
- At 90 days, multilayered titanium (66.84%) and tantalum (70.35%) implants maintained superior bone-implant contact compared to rough titanium (51.26%).
- Bone-implant volume at 90 days was highest for tantalum (51.2%) and multilayered titanium (48.43%), with rough titanium showing lower values (36.88%).
Conclusions:
- Titanium implants with 300-micron multilayered interlaced pores and tantalum implants with 300-micron pores (80% porosity) exhibit promising osseointegration.
- Rough-surface titanium implants possess osseointegrative capabilities, though less effective than the other tested materials.
- Surface topography engineered via 3D printing significantly impacts implant osseointegration.
Related Concept Videos
01:40Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:27Fractures: Bone Repair
3.3K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.3K
01:26Bone Markings
5.4K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
5.4K