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Updated: Jul 15, 2025
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
Published on: March 7, 2017
[Pediatric-Type Diffuse High-Grade Gliomas]
1Department of Neurosurgery, Brain Research Institute, Niigata University.
Insights
The 5th edition WHO classification defines pediatric-type diffuse high-grade gliomas, necessitating advanced diagnostics. New treatments are urgently needed, especially for diffuse midline glioma, H3 K27-altered, due to its poor prognosis.
Area of Science:
- Neuro-oncology
- Pediatric Pathology
- Molecular Diagnostics
Abstract:
Pediatric-type diffuse high-grade glioma is a new tumor class defined in the 5th edition of the WHO Classification of Tumors of the Central Nervous System(WHO2021). The class includes the following four tumor types: diffuse midline glioma, H3 K27-altered; diffuse hemispheric glioma, H3 G34-mutant; diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; and infant-type hemispheric glioma. Genetic detection of histone H3 mutations as well as detection of fusion genes and even methylation classifiers may be necessary to diagnose these tumors. Therefore, understanding their clinical and radiographical features is vital. Urgent establishment of new treatments is necessary for diffuse midline glioma, H3 K27-altered, as it is associated with very poor prognosis and is generally resistant to temozolomide. In this chapter, we focus on the clinical, radiographical, pathological, and molecular features of pediatric-type diffuse high-grade gliomas and introduce promising new treatments for diffuse midline glioma, H3 K27-altered.
