Majocchi's granuloma-A multicenter retrospective cohort study

Area of Science:

• Dermatology
• Mycology
• Infectious Diseases

Background:

• Majocchi's granuloma (MG) is an uncommon deep fungal folliculitis primarily caused by dermatophytes.
• Limited data exists on predisposing factors, clinical features, and treatment of MG due to its rarity.

Purpose of the Study:

• To review institutional experience with Majocchi's granuloma.
• To analyze clinical characteristics, pathogens, and treatment outcomes for MG.

Main Methods:

• Retrospective analysis of a multicenter cohort of adult patients diagnosed with MG between 1992 and 2022.
• Involved analysis of 147 patients, including demographics, comorbidities, causative pathogens, and treatment regimens.

Main Results:

• The study included 147 patients (105 male, median age 55.6 years).
• Common predisposing factors included immunosuppressant and topical corticosteroid use.
• Trichophyton rubrum was the most frequent pathogen; oral terbinafine was the primary treatment, achieving 96.6% clinical resolution.

Conclusions:

• Majocchi's granuloma, though rare and variable, requires histopathologic confirmation for diagnosis.
• Prolonged systemic antifungal therapy, such as oral terbinafine, is crucial for mycological cure.