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Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
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A spiropyran-decorated nanocoating for dynamically regulating bacteria/cell adhesion and detachment
Jie Li1, Zhuang Ma1, Anran Li1
1Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. zhangxinge@nankai.edu.cn.
Journal of Materials Chemistry. B
|September 25, 2023
Summary
This study presents a novel nanocoating that reversibly controls cell and bacteria adhesion using light and acidity. This stimuli-responsive biomaterial offers a new approach for preventing biomedical device contamination and failure.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Surface Chemistry
Background:
- Biomaterial contamination by microorganisms is a significant cause of biomedical device failure.
- Stimuli-responsive materials with reversible on-off states are gaining interest for dynamic control.
- Developing controllable surfaces is crucial for advanced biomedical applications.
Purpose of the Study:
- To develop a facile self-assembled nanocoating for reversible control of cell and bacteria adhesion.
- To utilize spiropyran-modified nanoparticles for acidity- and photo-regulated surface interactions.
- To create a dynamic biomaterial surface for potential biomedical device applications.
Main Methods:
- Fabrication of a nanocoating using spiropyran-conjugated nanoparticles on silica gel.
- Application of acidity and light stimuli to regulate nanoparticle interactions.
- Testing the reversibility and efficiency of bacteria and mammalian cell adhesion-and-detachment cycles.
Main Results:
- A self-assembled nanocoating was successfully constructed using spiropyran-modified nanoparticles.
- The nanocoating demonstrated efficient, reversible control over bacteria and mammalian cell adhesion and detachment.
- The stimuli-responsive adhesion-and-detachment function was maintained effectively over multiple cycles (≥8).
Conclusions:
- The developed nanocoating offers a dynamic and reversible platform for controlling cell and bacteria adhesion.
- Acidity and light stimuli provide effective on-off switching for regulating surface interactions.
- This approach shows significant promise for improving biomedical devices and preventing biomaterial contamination.
