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Conserved mechanisms of NuRD function in hematopoetic gene expression

Jonathan Lenz1, Alexander Brehm1

  • 1Institute for Molecular Biology and Tumor Research, Biomedical Research Center, Philipps-University Marburg, Marburg, Germany.

The Enzymes
|September 25, 2023
PubMed
Summary

The Nucleosome Remodeling and Deacetylating Complex (NuRD) works with transcription factors to control gene expression during cell differentiation. Understanding this interaction offers new therapeutic targets for blood disorders like hemoglobinopathies.

Keywords:
ChromatinDifferentiationEvolutionary conservationFOG1GATA transcription factorsGene regulationHematopoiesisNucleosome Remodeling and Decetylating (NuRD) complexNucleosome remodelingProtein interaction

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