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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jul 15, 2025

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Dermatofibrosarcoma Protuberans: A Surgeon's Enigma.

Siva M Gangadhar1, Mithilesh Yadav1, Nishith S Mandal1

  • 1Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.

Cureus
|September 27, 2023
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberans (DFSP) is a rare soft-tissue tumor with high recurrence rates. Early diagnosis and complete wide local excision are crucial for successful management and to prevent patient morbidity.

Keywords:
chemoradiotherapy (chemo-rt)dermatofibrosarcoma protuberansimmunohistochemistry (ihc)local recurrencewide excision

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive soft-tissue neoplasm originating in the dermis.
  • DFSP is characterized by a high propensity for local recurrence, necessitating precise management strategies.
  • Standard treatment involves wide local excision (WLE) aiming for tumor-negative margins (R0 resection) or Mohs micrographic surgery (MMS).

Observation:

  • A 57-year-old male presented with a recurrent, ulcerated mass on the anterior abdominal wall, having undergone two prior excisions elsewhere.
  • Incisional biopsy confirmed Dermatofibrosarcoma protuberans (DFSP).
  • The patient was treated with wide local excision (WLE) and subsequent flap reconstruction.

Findings:

  • Post-operative histopathology confirmed DFSP with achieved tumor-free margins (R0 resection).
  • The case highlights the importance of accurate diagnosis and complete resection in managing DFSP.

Implications:

  • Failure to diagnose and manage DFSP effectively in early stages significantly increases the risk of recurrence.
  • Timely and appropriate surgical intervention is essential to minimize morbidity associated with recurrent DFSP.
  • This case underscores the need for vigilance in differentiating DFSP from more common skin tumors to ensure optimal patient outcomes.