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ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database.

Madison Feshuk1, Lori Kolaczkowski2, Sean Watford3

  • 1Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Washington, DC, United States.

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|September 27, 2023
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The Toxicity Reference Database (ToxRefDB) now includes recovered data after a compilation error. This update enhances its utility for chemical safety assessments and toxicological research.

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Area of Science:

  • Toxicology
  • Environmental Health
  • Chemical Safety

Background:

  • The Toxicity Reference Database (ToxRefDB) compiles in vivo study data for over 1,100 chemicals.
  • It includes details on study design, chemical exposure, dosing, and observed effects.

Purpose of the Study:

  • To address and correct a compilation error in ToxRefDB v2.0.
  • To restore inadvertently omitted effect data and improve database accuracy.

Main Methods:

  • The update focused on data recovery and correction, not the addition of new studies.
  • Existing data compilation processes were reviewed to rectify the error.

Main Results:

  • Compilation error in ToxRefDB v2.0 leading to omitted effect data has been resolved.
  • ToxRefDB v2.1 now contains the complete, recovered dataset.

Conclusions:

  • The corrected ToxRefDB v2.1 enhances its value as a resource for curated in vivo toxicological information.
  • This improved resource supports in vitro screening, retrospective analysis, and predictive toxicology.