Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cholinesterases: Distribution and Function

Cholinesterases: Distribution and Function

Cholinesterases are a group of serine hydrolase enzymes that play a crucial role in the breakdown of choline esters. The two primary types of cholinesterases are acetylcholinesterases (AChEs) and butyrylcholinesterase (BuChEs), which differ in their distribution, function, and substrate specificity. AChEs, also known as true cholinesterases, specifically hydrolyze acetylcholine, while BuChEs, often referred to as pseudocholinesterases, can hydrolyze various choline esters, including...

Bacterial Phylum Chlamydiae

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...

Cholinergic Antagonists: Pharmacokinetics

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Safety Assessment of <i>Melaleuca alternifolia</i> (Tea Tree)-Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026

Same authorSame journal

Safety Assessment of Radish Root - Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026

Same authorSame journal

Amended Safety Assessment of Naturally-Sourced Clays as Used in Cosmetics.

International journal of toxicology·2026

Same author

Safety Assessment of Diatomaceous Earth as Used in Cosmetics.

International journal of toxicology·2026

Same author

Safety Assessment of Basic Yellow 87 as Used in Cosmetics.

International journal of toxicology·2026

Same author

Safety Assessment of Glycolactones as Used in Cosmetics.

International journal of toxicology·2026

Same journal

Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity.

International journal of toxicology·2026

Same journal

Nonclinical Safety Profiles of mRNA Therapeutics Comprising Unmodified or N1-Methyl-Pseudouridine-Modified Nucleosides Are Similar Following Repeated Administration.

International journal of toxicology·2026

Same journal

Evaluation of the <i>in vitro</i> Toxicity of Novel Oxime Acetylcholinesterase Reactivators.

International journal of toxicology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 15, 2025

Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole

Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole

Published on: June 7, 2022

Choleth-24.

Priya Cherian¹, Wilma F Bergfeld², Donald V Belsito³

¹Cosmetic Ingredient Review Senior Scientific Analyst/Writer.

International Journal of Toxicology

|September 27, 2023

Summary

This summary is machine-generated.

The Expert Panel for Cosmetic Ingredient Safety reaffirmed that Choleth-24 is safe for topical use in cosmetics. Updated reviews confirm its safety for human skin applications at specified concentrations and usage patterns.

Keywords:

Choleth-24 Cosmetics Safety

More Related Videos

Antibody Staining in C. Elegans Using "Freeze-Cracking"

Antibody Staining in C. Elegans Using "Freeze-Cracking"

Published on: October 14, 2013

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jul 15, 2025

Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole

Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole

Published on: June 7, 2022

Antibody Staining in C. Elegans Using "Freeze-Cracking"

Antibody Staining in C. Elegans Using "Freeze-Cracking"

Published on: October 14, 2013

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

High-throughput Nitrobenzoxadiazole-labeled Cholesterol Efflux Assay

Published on: January 7, 2019

Area of Science:

Cosmetic Science
Dermatology
Toxicology

Background:

The safety of cosmetic ingredients is periodically reassessed based on new scientific data.
Choleth-24 was previously evaluated by the Expert Panel in 1982.

Purpose of the Study:

To review updated information on Choleth-24, including product types, usage frequency, and concentrations.
To reaffirm the safety conclusion for Choleth-24 in topical cosmetic applications.

Main Methods:

The Expert Panel for Cosmetic Ingredient Safety conducted a review of newly available scientific information.
The review considered updated data on cosmetic product formulations and consumer exposure patterns.

Main Results:

Updated information regarding product types, frequency, and concentrations of use was assessed.
The panel reviewed new data that became available since the original 1982 assessment.

Conclusions:

The Expert Panel reaffirmed that Choleth-24 is safe for topical applications to humans.
Safety is confirmed within the described practices of use and concentration levels outlined in the report.