The clinical implications of choroidal thickness combined with tear VEGFA in coronary artery disease

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Tingquan Zhou1, Ting Wan2, Xian Jin1

  • 1Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine.

Coronary Artery Disease
|September 27, 2023
PubMed

Insights

Choroidal thickness and tear vascular endothelial growth factor A (VEGFA) show promise as biomarkers for coronary artery disease (CAD). Combining these markers accurately predicts CAD and its severity.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Identifying reliable biomarkers for early detection and severity assessment of CAD is crucial.

Purpose of the Study:

  • To investigate choroidal thickness and tear vascular endothelial growth factor A (VEGFA) as potential biomarkers for CAD.
  • To evaluate the combined diagnostic and prognostic value of these markers in patients undergoing coronary angiography.

Main Methods:

  • Retrospective observational case-control study including 637 patients.
  • Measurement of choroidal thickness via optical coherence tomography angiography.
  • Quantification of tear VEGFA levels.
  • Analysis using ROC curves and binary logistic regression.

Main Results:

  • Patients with CAD exhibited significantly thinner central foveal choroids compared to controls.
  • Elevated tear VEGFA levels were observed in patients with CAD.
  • Both markers showed significant correlations with the Gensini score, indicating disease severity.
  • The combined analysis yielded a high area under the curve (AUC) of 0.9647 for CAD detection.

Conclusions:

  • Choroidal thickness and tear VEGFA are significantly altered in patients with CAD.
  • The combination of these biomarkers demonstrates high accuracy in identifying CAD and assessing its severity.
  • This combined approach may offer a novel, non-invasive method for CAD evaluation.
Abstract

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