Pulmonary and hepatic lesions in experimental 3-hydroxymethylindole intoxication

Histopathological examination of liver and lung in guinea pigs experimentally intoxicated by 3HMI, a degradation product of an allelochemic of Brassica spp, showed the harmful effects of this compound on these organs. The 3HMI produces a hepatic steatosis and interstitial pneumonia with septal hyperemia. These results suggest that the 3HMI could develop a synergic toxic action together with skatole (3MI) as inducing agents of different forms of some diseases detected in cattle grazing Brassica pasture.