Insights into Microbiota in Sjögren's Syndrome

Area of Science:

• Immunology
• Microbiology
• Rheumatology

Background:

• Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder with unknown pathogenesis.
• The microbiota's role in autoimmune diseases is increasingly recognized.
• Potential mechanisms include molecular mimicry and epithelial barrier dysfunction.

Purpose of the Study:

• To review recent research on microbiota alterations in pSS.
• To explore microbial mechanisms contributing to pSS pathogenesis.
• To summarize current knowledge on the gut microbiome in Sjögren's syndrome.

Main Methods:

• Systematic literature search of PubMed, Web of Science, Scopus, and Cochrane Library.
• Analysis of studies investigating microbiota composition and function in pSS patients.
• Synthesis of data on microbial pathways implicated in SS.

Main Results:

• Significant alterations in microbiota composition are observed in pSS.
• Microbial metabolites and immune interactions are implicated in disease development.
• The gut microbiome influences key pathogenic pathways in Sjögren's syndrome.

Conclusions:

• The microbiota plays a substantial role in the pathogenesis and progression of pSS.
• Targeting the microbiota may offer novel therapeutic strategies for pSS.
• Further research into microbiota-host interactions is crucial for managing this autoimmune condition.