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Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
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Phages for treatment Pseudomonas aeruginosa infection

Salsabil Makky1, Fatma Abdelrahman1, Nouran Rezk1

  • 1Center for Microbiology and Phage Therapy, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, Egypt.

Progress in Molecular Biology and Translational Science
|September 28, 2023
PubMed

Insights

Bacteriophage therapy offers a promising alternative to antibiotics for combating drug-resistant Pseudomonas aeruginosa. This approach utilizes phages, viruses that infect bacteria, to target and eliminate this public health threat.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacteriophage Research

Background:

  • Pseudomonas aeruginosa is a major public health concern due to its virulence factors and widespread antibiotic resistance.
  • Conventional antibiotics are increasingly ineffective against multidrug-resistant strains of P. aeruginosa.

Purpose of the Study:

  • To review the virulence factors and antibiotic resistance genes in P. aeruginosa.
  • To highlight recent advancements in bacteriophage therapy against P. aeruginosa.
  • To discuss regulatory aspects of phage therapy.

Main Methods:

  • Literature review of P. aeruginosa virulence and resistance.
  • Analysis of studies on various phage therapy strategies (wild-type, modified, cocktails, combination therapy).
  • Examination of phage efficacy against planktonic and biofilm forms of P. aeruginosa.

Main Results:

  • P. aeruginosa possesses significant virulence factors and a high prevalence of antibiotic resistance genes.
  • Various phage-based strategies show efficacy against P. aeruginosa, including in biofilm states.
  • Recent regulations are emerging to guide phage therapy applications.

Conclusions:

  • Bacteriophage therapy presents a viable alternative to antibiotics for treating P. aeruginosa infections.
  • Phage therapy, in its diverse forms, is a developing field with significant potential.
  • Further research and regulatory clarity are crucial for the widespread adoption of phage therapy.
Keywords:
Antibiotic resistanceBacteriophageP. aeruginosaPhage therapyTreatment

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