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Updated: Aug 3, 2026
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Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
Spontaneous resolution of herpes simplex blepharoconjunctivitis in children
American Journal of Ophthalmology
|November 15, 1986
Summary
Herpes simplex blepharoconjunctivitis in children often resolves without treatment. One case showed adverse reactions to vidarabine, resolving after discontinuation, suggesting benign outcomes for this ocular infection.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Herpes simplex virus (HSV) can cause ocular infections in children.
- Blepharoconjunctivitis is an inflammation of the eyelids and conjunctiva.
Observation:
- Three children with herpes simplex blepharoconjunctivitis showed spontaneous resolution without antiviral therapy.
- A fourth child experienced probable toxic effects from topical vidarabine treatment.
Findings:
- Herpes simplex ocular infections in children, without corneal involvement, are typically self-limiting.
- Discontinuation of vidarabine led to the resolution of both toxic manifestations and blepharoconjunctivitis.
Implications:
- This suggests a conservative management approach may be suitable for uncomplicated pediatric herpes simplex blepharoconjunctivitis.
- Careful monitoring for adverse effects is crucial when using antiviral medications in children.
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