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Antifouling Surfaces Based on Polyzwitterion Loop Brushes.
Xiaoyu Xia1,2, Xiaodie Yuan1, Guangyu Zhang1
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
ACS Applied Materials & Interfaces
|September 29, 2023
Summary
Loop polyzwitterionic coatings show superior antifouling properties. These novel surfaces effectively resist protein, platelet, and bacterial adhesion, offering advanced protection in various applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Surface Chemistry
Background:
- Antifouling surfaces are crucial for preventing unwanted material adhesion in diverse applications.
- Developing surfaces with robust resistance to protein and cell adsorption remains a significant challenge.
Purpose of the Study:
- To synthesize and characterize novel loop polyzwitterionic coatings.
- To evaluate the antifouling performance of these coatings against protein, platelet, and bacterial adhesion.
- To compare the efficacy of loop versus linear polyzwitterion brush architectures.
Main Methods:
- Synthesis of triblock and diblock copolymers via atom-transfer radical polymerization.
- Surface immobilization onto gold substrates via thiol-terminated polymer brushes.
- Characterization using X-ray photoelectron spectroscopy and ellipsometry.
- Assessment of protein adsorption using quartz crystal microbalance with dissipation.
- Evaluation of cell and bacterial adhesion using confocal laser scanning microscopy and scanning electron microscopy.
Main Results:
- Successfully created loop and linear poly(sulfobetaine methacrylate) (PSBMA) brush coatings.
- Both architectures demonstrated excellent resistance to protein adsorption (bovine serum albumin, fibrinogen).
- Loop polyzwitterion brushes exhibited superior antifouling performance compared to linear analogues.
- Effective reduction in platelet and bacterial adhesion was observed on both types of coatings.
Conclusions:
- Loop polyzwitterionic coatings offer enhanced antifouling capabilities.
- The loop architecture provides superior resistance to biofouling compared to linear brushes.
- These findings highlight the potential of polyzwitterionic loop brushes for advanced antifouling applications.
