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Long non-coding RNAs and pancreatic cancer: A multifaceted view
Bin Wang1, Chang Yuan1, Yinyin Qie2
1General Surgery Department, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212000, China.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 29, 2023
Summary
Long non-coding RNAs (lncRNAs) are increasingly linked to pancreatic cancer (PC) development, influencing proliferation, metastasis, and chemoresistance. Understanding lncRNA roles offers new diagnostic and therapeutic strategies for this deadly cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Pancreatic cancer (PC) has a dismal 5-year survival rate (10%) due to late detection and unclear molecular mechanisms.
- Risk factors include family history, type 2 diabetes, and pancreatitis.
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators in various cancers.
Purpose of the Study:
- To review the current understanding of lncRNA involvement in pancreatic cancer.
- To explore the role of lncRNAs in PC progression, including metastasis, angiogenesis, and chemoresistance.
- To highlight the potential of lncRNAs as biomarkers and therapeutic targets for PC.
Main Methods:
- Literature review of recent studies on lncRNAs in pancreatic cancer.
- Analysis of lncRNA functions in PC proliferation, invasion, and metastasis.
- Examination of lncRNA regulation in the tumor microenvironment and response to chemotherapy.
Main Results:
- Abnormal lncRNA regulation is implicated in key PC pathological processes.
- lncRNAs influence PC cell proliferation, metastasis, angiogenesis, apoptosis, and chemotherapy resistance.
- lncRNAs are associated with risk factors like diabetes mellitus and pancreatitis.
Conclusions:
- lncRNAs play a significant role in the development and progression of pancreatic cancer.
- lncRNAs demonstrate potential as diagnostic biomarkers and therapeutic targets for PC.
- Further research into lncRNAs could improve PC patient outcomes and survival rates.
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