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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
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Radiological evaluation of an iodised hydrogel for prostate radiotherapy applications
Alannah Kejda1, Regina Bromley1, Linda Bell1
1Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Summary
SpaceOAR Vue™, an iodized hydrogel, is suitable for prostate radiotherapy. It provides anatomical separation, is radio-opaque on kV images, and dosimetrically behaves like water in MV treatment beams, improving patient safety.
Area of Science:
- Radiotherapy physics
- Medical imaging
- Biomaterials
Background:
- Hydrogels physically separate healthy tissue from target volumes in prostate radiotherapy, potentially reducing patient toxicity.
- Iodized hydrogels offer radio-opacity for visualization and anatomical separation of the prostate and rectum.
Purpose of the Study:
- To characterize SpaceOAR Vue™ in kilovoltage (kV) images.
- To evaluate its performance in megavoltage (MV) radiotherapy treatment planning.
Main Methods:
- Transmission dose measurements were performed using water and SpaceOAR Vue™ in slab phantoms for 6MV and 10MV photon energies.
- CT and treatment planning simulations were conducted, comparing calculated doses to measured doses.
- Clinical assessment of SpaceOAR Vue™ in 5 patients included evaluation of volume and Hounsfield units (HU) in CT and CBCT imaging.
Main Results:
- Transmission dose through SpaceOAR Vue™ agreed within 0.5% of water for both photon energies.
- Treatment planning dose calculations, with SpaceOAR Vue™ segmented as water, agreed within 0.5% of measured doses.
- Clinically, SpaceOAR Vue™ volume and HU remained stable, though its appearance varied across kV imaging modalities.
Conclusions:
- SpaceOAR Vue™ is radio-opaque on kV images.
- It exhibits water-equivalent dosimetric properties in MV treatment beams.
- These characteristics make SpaceOAR Vue™ suitable for clinical application in prostate radiotherapy.
