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Updated: Jul 15, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Reprograming cancer cells by a BODIPY G-quadruplex stabiliser
Aminesena Baser1, Beyza Basar2,3, Hanim Beyza Dogan1
1Konya Food and Agriculture University, Beysehir Cd. No: 9 Meram, Konya, Turkey.
Abstract:
A cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1α, VIM, CDH1) related to metastasis is modulated. The stabiliser reprograms hypoxia-adaptive metabolism and an 1.82-fold increase in O2 consumption, enabling back-to-normal switching of energy metabolism, is observed. Stabilisers with a strong G-quadruplex affinity (0.38 μM Kd) significantly contribute to small molecule anti-cancer approaches.
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