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Related Experiment Video

Updated: Jul 15, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Right Ventricular Function Indices at Rest and During Exercise in Hyperthyroid Patients: A Cross-sectional Study.

Khadije Mohammadi1, Maryam Shojaeifard2, Marzieh Mirtajaddini3

  • 1Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Iranian Journal of Medical Sciences
|October 4, 2023
PubMed
Summary

Hyperthyroidism significantly impairs right ventricular (RV) function, particularly during stress. Early evaluation of RV function is crucial for hyperthyroid patients to prevent adverse outcomes.

Keywords:
EchocardiographyExercise testHyperthyroidismVentricular function, right

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Area of Science:

  • Cardiology
  • Endocrinology
  • Diagnostic Imaging

Background:

  • Hyperthyroidism is linked to potential right ventricular (RV) dysfunction.
  • Strain echocardiography offers a detailed assessment of RV function.

Purpose of the Study:

  • To investigate RV function in hyperthyroid patients using strain echocardiography.
  • To compare RV function at rest and during maximum stress between hyperthyroid patients and controls.

Main Methods:

  • A cross-sectional study involving 52 participants (26 hyperthyroid, 26 controls).
  • Two-dimensional echocardiography and maximum treadmill exercise test were performed.
  • RV function indices were analyzed at rest and peak stress.

Main Results:

  • Hyperthyroid patients showed significantly reduced RV global longitudinal strain, systolic and diastolic strain rates, and tricuspid annular plane systolic excursion during maximal stress.
  • A significant linear correlation was found between RV size and thyroid-stimulating hormone (TSH) levels.
  • TSH levels negatively correlated with maximum stress RV strain and diastolic strain rate.

Conclusions:

  • Hyperthyroidism significantly alters RV function indices, especially under stress.
  • Early diagnosis and treatment of hyperthyroidism are essential.
  • Routine RV function evaluation should be considered in hyperthyroid patients.