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Updated: Jul 15, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Tyrosine kinase inhibitors induced thyroid dysfunction: myth or reality?
Anjli Malhotra1, Rajeev Gupta1, Shveta Mahajan2
1Department of Medicine, SGRD Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Background:
Chronic myelogenous leukemia (CML) is a hematopoietic stem cell disorder. It is associated with acquired genetic changes in the hematopoietic stem cells in the form of BCR-ABL fusion gene also known as Philadelphia chromosome.
Materials And Methods:
We prospectively studied thyroid function at baseline and at 6 months of imatinib treatment in 26 newly diagnosed BCR-ABL positive CML patients.
Result:
The thyroid-stimulating hormone (TSH) levels increased significantly from baseline (3.20 ± 0.978 mIU/L vs. 3.724 ± 1.726 mIU/L, p < 0.05) after 6 months of treatment, 88.4% of the patients remained euthyroid. Only 2 patients had subclinical hypothyroidism, 1 had hypothyroidism after 6 months of tyrosine kinase inhibitors (TKI) therapy.
Conclusion:
Imatinib did not have any significant effect on thyroid function in CML patients in this study.
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