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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

266
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
266
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

199
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
199
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

137
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
137
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

341
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
341
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

161
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
161
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

464
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
464

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Related Experiment Video

Updated: Jul 14, 2025

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Altered voxel-based and surface-based morphometry in inflammatory bowel disease.

Jennifer Kornelsen1, Theresa McIver2, Md Nasir Uddin3

  • 1Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg Health Sciences Centre, Winnipeg, MB, Canada; University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.

Brain Research Bulletin
|October 5, 2023
PubMed
Summary
This summary is machine-generated.

Brain structure differences in inflammatory bowel disease (IBD) were explored. Adults with IBD showed significant left-lateralized cortical thinning and greater cortical complexity compared to controls.

Keywords:
Brain structureCortical complexityCortical thicknessCrohn’s diseaseIBDInflammatory bowel diseaseSurface-based morphometryUlcerative colitisVoxel-based morphometry

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Last Updated: Jul 14, 2025

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Area of Science:

  • Neuroimaging
  • Gastroenterology
  • Brain-Gut Axis Research

Background:

  • Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, involves gastrointestinal inflammation and brain-gut axis dysfunction.
  • Neuroimaging studies are crucial for understanding the brain-gut interplay and comorbidities in IBD patients.

Purpose of the Study:

  • To investigate brain structure differences in adults with IBD compared to healthy controls using multiple neuroimaging metrics.
  • To explore the relationship between disease duration and brain structure in individuals with IBD.

Main Methods:

  • Utilized voxel-based morphometry and surface-based morphometry to assess grey matter volume, cortical thickness, gyrification, cortical complexity, and sulcal depth.
  • Compared brain structure metrics between 72 adults with IBD and 90 healthy controls.

Main Results:

  • Significant findings included left-lateralized cortical thinning and increased cortical complexity in the left fusiform and right posterior cingulate gyrus in the IBD group.
  • No significant differences were observed in grey matter volume, gyrification, or sulcal depth between groups.
  • Post hoc analysis revealed an association between disease duration and right supramarginal gyrus cortical complexity within the IBD cohort.

Conclusions:

  • Brain structure alterations, specifically cortical thinning and altered complexity, are present in adults with IBD.
  • These findings highlight the impact of IBD on brain structure and support the concept of a disrupted brain-gut axis.