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Related Experiment Videos

Epicutaneous testing.

M Hannuksela

    Allergy
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Standardized patch and chamber tests detect delayed contact allergies. New methods are needed for photocutaneous testing and Type I allergies, like contact urticaria.

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    Area of Science:

    • Dermatology
    • Allergology
    • Contact Hypersensitivity

    Background:

    • Standardized methods like patch and chamber tests are used for delayed contact allergies.
    • Open testing is employed for challenging chemicals, but photocutaneous testing faces standardization issues.
    • Type I contact allergies are more prevalent than previously thought, particularly in birch pollen-allergic individuals.

    Purpose of the Study:

    • To review current methodologies for detecting contact allergies.
    • To highlight challenges in standardizing photocutaneous allergy testing.
    • To discuss methods for examining Type I contact allergies and contact urticaria.

    Main Methods:

    • Review of established diagnostic techniques: patch test, chamber test, and open testing.

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  • Discussion of photocutaneous testing variables: occlusion, vehicle composition, and light sources (xenon arc, fluorescent black light).
  • Exploration of techniques for Type I allergies and contact urticaria: scratch chamber, scarification chamber, and open testing on compromised skin.

    • Main Results:

    • Patch and chamber tests are well-standardized for delayed contact allergies.
    • Photocutaneous testing lacks standardization due to variable protocols.
    • Type I contact allergies and contact urticaria can be assessed using specific chamber techniques and open testing.

    Conclusions:

    • While delayed contact allergy testing is standardized, photocutaneous testing requires further standardization.
    • Emerging evidence suggests Type I contact allergies are common and require specific diagnostic approaches.
    • Further research into standardized photocutaneous and Type I allergy testing is warranted.